Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity.
Identifieur interne : 001A91 ( Main/Exploration ); précédent : 001A90; suivant : 001A92Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity.
Auteurs : RBID : pubmed:20387796English descriptors
- KwdEn :
- Adipose Tissue (cytology), Animals, Cadmium (chemistry), Color, Copper (chemistry), Copper (toxicity), Female, Indium (chemistry), Indium (toxicity), Inflammation (chemically induced), Infrared Rays, Lymph Nodes (metabolism), Lymphatic Metastasis (diagnosis), Mice, Molecular Imaging (methods), Photochemical Processes, Quantum Dots, Sentinel Lymph Node Biopsy, Solubility, Sulfides (chemical synthesis), Sulfides (chemistry), Sulfides (toxicity), Surface Properties, Water (chemistry), Zinc Compounds (chemical synthesis), Zinc Compounds (chemistry), Zinc Compounds (toxicity).
- MESH :
- chemical , chemical synthesis : Sulfides, Zinc Compounds.
- chemical , chemistry : Cadmium, Copper, Indium, Sulfides, Water, Zinc Compounds.
- chemically induced : Inflammation.
- cytology : Adipose Tissue.
- diagnosis : Lymphatic Metastasis.
- metabolism : Lymph Nodes.
- methods : Molecular Imaging.
- chemical , toxicity : Copper, Indium, Sulfides, Zinc Compounds.
- Animals, Color, Female, Infrared Rays, Mice, Photochemical Processes, Quantum Dots, Sentinel Lymph Node Biopsy, Solubility, Surface Properties.
Abstract
Semiconductor quantum dots (QDs) could significantly impact the performance of biomedical near-infrared (NIR) imaging by providing fluorescent probes that are brighter and more photostable than conventional organic dyes. However, the toxicity of the components of NIR emitting II-VI and IV-VI QDs that have been made so far (Cd, Hg, Te, Pb, etc.) has remained a major obstacle to the clinical use of QDs. Here, we present the synthesis of CuInS(2)/ZnS core/shell QDs emitting in the NIR ( approximately 800 nm) with good quantum yield and stability even after transfer into water. We demonstrate the potential of these QDs by imaging two regional lymph nodes (LNs) in vivo in mice. We then compare the inflammatory response of the axillary LN induced by different doses of CuInS(2)/ZnS and CdTeSe/CdZnS QDs and show a clear difference in acute local toxicity, the onset of inflammation only occurring at a 10 times more concentrated dose for CuInS(2)/ZnS QDs than for their Cd-containing counterparts.
DOI: 10.1021/nn901421v
PubMed: 20387796
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity.</title><author><name sortKey="Pons, Thomas" uniqKey="Pons T">Thomas Pons</name><affiliation wicri:level="3"><nlm:affiliation>Laboratoire Physique et Etude des Matériaux, CNRS UPR0005, ESPCI, 10 rue Vauquelin, 75005 Paris, France. thomas.pons@espci.fr</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire Physique et Etude des Matériaux, CNRS UPR0005, ESPCI, 10 rue Vauquelin, 75005 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Pic, Emilie" uniqKey="Pic E">Emilie Pic</name></author><author><name sortKey="Lequeux, Nicolas" uniqKey="Lequeux N">Nicolas Lequeux</name></author><author><name sortKey="Cassette, Elsa" uniqKey="Cassette E">Elsa Cassette</name></author><author><name sortKey="Bezdetnaya, Lina" uniqKey="Bezdetnaya L">Lina Bezdetnaya</name></author><author><name sortKey="Guillemin, Francois" uniqKey="Guillemin F">François Guillemin</name></author><author><name sortKey="Marchal, Frederic" uniqKey="Marchal F">Frédéric Marchal</name></author><author><name sortKey="Dubertret, Benoit" uniqKey="Dubertret B">Benoit Dubertret</name></author></titleStmt><publicationStmt><date when="2010">2010</date><idno type="doi">10.1021/nn901421v</idno><idno type="RBID">pubmed:20387796</idno><idno type="pmid">20387796</idno><idno type="wicri:Area/Main/Corpus">001981</idno><idno type="wicri:Area/Main/Curation">001981</idno><idno type="wicri:Area/Main/Exploration">001A91</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adipose Tissue (cytology)</term><term>Animals</term><term>Cadmium (chemistry)</term><term>Color</term><term>Copper (chemistry)</term><term>Copper (toxicity)</term><term>Female</term><term>Indium (chemistry)</term><term>Indium (toxicity)</term><term>Inflammation (chemically induced)</term><term>Infrared Rays</term><term>Lymph Nodes (metabolism)</term><term>Lymphatic Metastasis (diagnosis)</term><term>Mice</term><term>Molecular Imaging (methods)</term><term>Photochemical Processes</term><term>Quantum Dots</term><term>Sentinel Lymph Node Biopsy</term><term>Solubility</term><term>Sulfides (chemical synthesis)</term><term>Sulfides (chemistry)</term><term>Sulfides (toxicity)</term><term>Surface Properties</term><term>Water (chemistry)</term><term>Zinc Compounds (chemical synthesis)</term><term>Zinc Compounds (chemistry)</term><term>Zinc Compounds (toxicity)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Sulfides</term><term>Zinc Compounds</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Cadmium</term><term>Copper</term><term>Indium</term><term>Sulfides</term><term>Water</term><term>Zinc Compounds</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Adipose Tissue</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphatic Metastasis</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lymph Nodes</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Imaging</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Copper</term><term>Indium</term><term>Sulfides</term><term>Zinc Compounds</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Color</term><term>Female</term><term>Infrared Rays</term><term>Mice</term><term>Photochemical Processes</term><term>Quantum Dots</term><term>Sentinel Lymph Node Biopsy</term><term>Solubility</term><term>Surface Properties</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Semiconductor quantum dots (QDs) could significantly impact the performance of biomedical near-infrared (NIR) imaging by providing fluorescent probes that are brighter and more photostable than conventional organic dyes. However, the toxicity of the components of NIR emitting II-VI and IV-VI QDs that have been made so far (Cd, Hg, Te, Pb, etc.) has remained a major obstacle to the clinical use of QDs. Here, we present the synthesis of CuInS(2)/ZnS core/shell QDs emitting in the NIR ( approximately 800 nm) with good quantum yield and stability even after transfer into water. We demonstrate the potential of these QDs by imaging two regional lymph nodes (LNs) in vivo in mice. We then compare the inflammatory response of the axillary LN induced by different doses of CuInS(2)/ZnS and CdTeSe/CdZnS QDs and show a clear difference in acute local toxicity, the onset of inflammation only occurring at a 10 times more concentrated dose for CuInS(2)/ZnS QDs than for their Cd-containing counterparts.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20387796</PMID><DateCreated><Year>2010</Year><Month>05</Month><Day>25</Day></DateCreated><DateCompleted><Year>2010</Year><Month>09</Month><Day>07</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1936-086X</ISSN><JournalIssue CitedMedium="Internet"><Volume>4</Volume><Issue>5</Issue><PubDate><Year>2010</Year><Month>May</Month><Day>25</Day></PubDate></JournalIssue><Title>ACS nano</Title><ISOAbbreviation>ACS Nano</ISOAbbreviation></Journal><ArticleTitle>Cadmium-free CuInS2/ZnS quantum dots for sentinel lymph node imaging with reduced toxicity.</ArticleTitle><Pagination><MedlinePgn>2531-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1021/nn901421v</ELocationID><Abstract><AbstractText>Semiconductor quantum dots (QDs) could significantly impact the performance of biomedical near-infrared (NIR) imaging by providing fluorescent probes that are brighter and more photostable than conventional organic dyes. However, the toxicity of the components of NIR emitting II-VI and IV-VI QDs that have been made so far (Cd, Hg, Te, Pb, etc.) has remained a major obstacle to the clinical use of QDs. Here, we present the synthesis of CuInS(2)/ZnS core/shell QDs emitting in the NIR ( approximately 800 nm) with good quantum yield and stability even after transfer into water. We demonstrate the potential of these QDs by imaging two regional lymph nodes (LNs) in vivo in mice. We then compare the inflammatory response of the axillary LN induced by different doses of CuInS(2)/ZnS and CdTeSe/CdZnS QDs and show a clear difference in acute local toxicity, the onset of inflammation only occurring at a 10 times more concentrated dose for CuInS(2)/ZnS QDs than for their Cd-containing counterparts.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pons</LastName><ForeName>Thomas</ForeName><Initials>T</Initials><Affiliation>Laboratoire Physique et Etude des Matériaux, CNRS UPR0005, ESPCI, 10 rue Vauquelin, 75005 Paris, France. thomas.pons@espci.fr</Affiliation></Author><Author ValidYN="Y"><LastName>Pic</LastName><ForeName>Emilie</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lequeux</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Cassette</LastName><ForeName>Elsa</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Bezdetnaya</LastName><ForeName>Lina</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Guillemin</LastName><ForeName>François</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Marchal</LastName><ForeName>Frédéric</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Dubertret</LastName><ForeName>Benoit</ForeName><Initials>B</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>ACS Nano</MedlineTA><NlmUniqueID>101313589</NlmUniqueID><ISSNLinking>1936-0851</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Sulfides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Zinc Compounds</NameOfSubstance></Chemical><Chemical><RegistryNumber>00BH33GNGH</RegistryNumber><NameOfSubstance>Cadmium</NameOfSubstance></Chemical><Chemical><RegistryNumber>045A6V3VFX</RegistryNumber><NameOfSubstance>Indium</NameOfSubstance></Chemical><Chemical><RegistryNumber>059QF0KO0R</RegistryNumber><NameOfSubstance>Water</NameOfSubstance></Chemical><Chemical><RegistryNumber>789U1901C5</RegistryNumber><NameOfSubstance>Copper</NameOfSubstance></Chemical><Chemical><RegistryNumber>KPS085631O</RegistryNumber><NameOfSubstance>zinc sulfide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Adipose Tissue</DescriptorName><QualifierName MajorTopicYN="N">cytology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Cadmium</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Color</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Copper</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium</DescriptorName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Inflammation</DescriptorName><QualifierName MajorTopicYN="N">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Infrared Rays</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lymph Nodes</DescriptorName><QualifierName MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Lymphatic Metastasis</DescriptorName><QualifierName MajorTopicYN="N">diagnosis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Molecular Imaging</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Photochemical Processes</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Quantum Dots</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sentinel Lymph Node Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Solubility</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sulfides</DescriptorName><QualifierName MajorTopicYN="N">chemical synthesis</QualifierName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Surface Properties</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Water</DescriptorName><QualifierName MajorTopicYN="N">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Zinc Compounds</DescriptorName><QualifierName MajorTopicYN="N">chemical synthesis</QualifierName><QualifierName MajorTopicYN="Y">chemistry</QualifierName><QualifierName MajorTopicYN="Y">toxicity</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2010</Year><Month>9</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1021/nn901421v</ArticleId><ArticleId IdType="pubmed">20387796</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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